ea0016p215 | Diabetes and cardiovascular diseases | ECE2008
Bobbert Thomas
, Mittag Marc
, Mai Knut
, Fischer Antje
, Arafat Ayman
, Pfeiffer AFH
, Spranger Joachim
The development of diabetes mellitus type 2 (T2DM) is affected by genetic and lifestyle factors. Polymorphisms within the KIR6.2 gene seem to be associated with a higher risk for T2DM. The protein encoded by this gene represents a potassium channel, which plays an essential role in insulin and glucagon secretion by the pancreas.A hyperglycaemic clamp without insulin was performed over 2 h in 10 healthy persons with the Kir6.2 E23K wild type Glu/Glu, 10 a...